Objectives: Proportion of population aged 60 years or over is expected to grow very rapidly in Korea and all over the world. Osteoporosis is one of the major geriatric diseases, however the study of osteoporotic vertebral fracture has been underestimated in osteoporotic fracture treatment. we have investigated persistence of osteoporosis medication and drug use factor in osteoporotic compression vertebral fracture patients.
Methods: Four hundred fifty-eight patients with osteoporotic vertebral fracture who underwent osteoporosis medication in our institution between January 2010 and February 2014, were retrospectively analyzed. Male to female ratio was 403:55. Mean patients age was 75yrs (range: 50?95). The persistence of osteoporotic medication were analyzed using Kaplan Meier survival analysis. Multiple factors analysis was performed using cox regression test. Gender, age, types of drugs, duration, kinds of doctors, change of drug were analyzed.
Results: Persistence of Osteoporotic medication were 52% at 6 month, 40% at 12 months, 28% at 24 months, 25% at 36 months. Women were higher persistence than men (p < 0.05). There is no difference between over 75yrs old patients and less (p > 0.05). Kinds of drugs and dose interval significantly affect persistence (p < 0.05). Persistence ratio was particularly higher in drug change group (p < 0.0001). There is no difference between kinds of doctors.
Conclusion: Overtime, persistence of osteoporotic medication in osteoporotic vertebral fracture patients sharply decreased. Changing drug group shows significantly higher sustained rate of the drug medication. Patients also took SERM for a longer period than bisphosphonate. The authors considered that prescribing physician will be able to increase the rate of osteoporosis drugs through the patient care and education. The results of the study are useful in increasing persistence of osteoporotic medicaiotion.
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